منابع مشابه
Protein design for pathway engineering.
Design and construction of biochemical pathways has increased the complexity of biosynthetically-produced compounds when compared to single enzyme biocatalysis. However, the coordination of multiple enzymes can introduce a complicated set of obstacles to overcome in order to achieve a high titer and yield of the desired compound. Metabolic engineering has made great strides in developing tools ...
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Often in modeling the engineering optimization design problems, the value of objective function(s) is not clearly defined in terms of design variables. Instead it is obtained by some numerical analysis such as FE structural analysis, fluid mechanic analysis, and thermodynamic analysis, etc. Yet, the numerical analyses are considerably time consuming to obtain the final value of objective functi...
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We describe a framework for designing the sequences of multiple nucleic acid strands intended to hybridize in solution via a prescribed reaction pathway. Sequence design is formulated as a multistate optimization problem using a set of target test tubes to represent reactant, intermediate, and product states of the system, as well as to model crosstalk between components. Each target test tube ...
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Protein structure design and engineering is a research endeavour in which proteins with predicted structure and function are constructed in the laboratory through rational design, combinatorial selection or combination of both approaches. It is built upon our knowledge about the structure and function of proteins and can be accomplished either from scratch (de novo design) or based on native sc...
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Cambridge University Chemical Laboratory, Cambridge University, Lensfield Road, Cambridge CB2 1EW, UK e-mail: [email protected] We chose this set of reviews to give a broad coverage of the current state of protein engineering and design. The topics chosen encompass basic design approaches to study protein structure and function, comparisons of the strengths and limitations of screens and selectio...
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ژورنال
عنوان ژورنال: Journal of Structural Biology
سال: 2014
ISSN: 1047-8477
DOI: 10.1016/j.jsb.2013.03.011